Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11742041 | 0.89 | PNMT (0.68) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| Hydrochloric Acid SCHEMBL11744098 | 0.88 | PNMT (0.69) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL476330 | 0.82 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL30249887 | 0.82 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| Hydrochloric Acid SCHEMBL158709 | 0.81 | PNMT (0.96) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL11340596 | 0.79 | PNMT (0.70) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL11335549 | 0.79 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CPRKACA | |
| SCHEMBL11336373 | 0.79 | PNMT (0.70) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL11322886 | 0.79 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CPRKACA | |
| SCHEMBL11322164 | 0.79 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |