SCHEMBL11335232

SCHEMBL11335232

CCC(c1ccccc1N)C1CCCCN1C

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CHRNB4 P30926 2/20 0.40
CHRNA3 P32297 2/20 0.40
OPRM1 P35372 1/20 0.36
OPRL1 P41146 1/20 0.36
ADRA2A P08913 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
MTOR P42345 1/20 0.35
PMP22 Q01453 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4649295 0.76 PKM (0.42) CYP1A2CYP3A4CYP2D6CYP2C9LMNA
SCHEMBL11319205 0.72 CHRNB4 (0.43) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL11322069 0.70 DRD1 (0.60) CYP1A2CYP2D6CYP2C9MAPT
SCHEMBL1795410 0.67 CHRNB4 (0.50) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL11609335 0.67 CHRNB4 (0.50) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL1797151 0.67 CHRNB4 (0.50) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL1794388 0.67 CHRNB4 (0.50) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL1797148 0.67 CHRNB4 (0.50) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL1795653 0.67 CHRNB4 (0.50) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL10905608 0.67 CHRNB4 (0.47) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE30812-E ANTIARRHTHMIA AGENTS MEAD JOHNSON & COMPANY (US) 1981-12-01 US disclosed
US-RE30811-E SEROTONIN ANTAGONISTS, ANTIARRHYTHMIA AGENTS MEAD JOHNSON & COMPANY (US) 1981-12-01 US disclosed
US-4064254-A ANTIARRHYTHMIC AND ANTISEROTONINE AGENTS MEAD JOHNSON & COMPANY (US) 1977-12-20 US disclosed
US-4000143-A ANTIARRHYTHMIC AND ANTISEROTONIN AGENTS MEAD JOHNSON & COMPANY (US) 1976-12-28 US disclosed
US-3931195-A ANTIARRHYTHMIA, ANTISEROTONIN MEAD JOHNSON & COMPANY (US) 1976-01-06 US disclosed