Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11336355 | 1.00 | SIGMAR1 (0.50) | SIGMAR1OPRK1KDM4EMEN1NPC1 | |
| SCHEMBL11343008 | 0.90 | SIGMAR1 (0.53) | SIGMAR1OPRK1KDM4EMEN1NPC1 | |
| SCHEMBL11339650 | 0.87 | SIGMAR1 (0.53) | SIGMAR1OPRK1KDM4EMEN1NPC1 | |
| SCHEMBL11446429 | 0.86 | SIGMAR1 (0.51) | SIGMAR1OPRK1KDM4EMEN1NPC1 | |
| SCHEMBL11454746 | 0.83 | SIGMAR1 (0.51) | SIGMAR1OPRK1KDM4EMEN1NPC1 | |
| SCHEMBL11333535 | 0.82 | NPC1 (0.44) | SIGMAR1OPRK1KDM4EMEN1NPC1 | |
| SCHEMBL11436334 | 0.80 | NPC1 (0.43) | OPRK1KDM4EMEN1NPC1MITF | |
| SCHEMBL11552261 | 0.80 | NPC1 (0.41) | OPRK1KDM4EMEN1NPC1MITF | |
| SCHEMBL11338319 | 0.79 | SIGMAR1 (0.44) | SIGMAR1OPRK1MEN1ALDH1A1RAB9A | |
| SCHEMBL11446508 | 0.79 | NPC1 (0.42) | SIGMAR1OPRK1KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |