SCHEMBL11337288

SCHEMBL11337288

N#Cc1ccc2c(=O)c3cc(C#N)ccc3oc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.50
NPC1 O15118 4/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
ADRB2 P07550 1/20 0.48
TLR9 Q9NR96 1/20 0.47
NOS3 P29474 1/20 0.46
NOS1 P29475 1/20 0.46
NOS2 P35228 1/20 0.46
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
GFER P55789 1/20 0.46
MAOA P21397 3/20 0.44
TTR P02766 2/20 0.43
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
GLA P06280 1/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28401034 0.93 RAB9A (0.51) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL11340455 0.93 MAPT (0.52) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL31161245 0.88 MAOA (0.60) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL16117996 0.88 RAB9A (0.64) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL11373382 0.88 MAOA (0.60) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL10453646 0.85 CYP2A6 (0.44) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL10453458 0.85 NPC1 (0.68) RAB9ANPC1MEN1KMT2ATLR9
SCHEMBL10452832 0.85 TLR9 (0.42) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL11554110 0.85 CYP2A6 (0.44) RAB9ANPC1L3MBTL1MEN1KMT2A
SCHEMBL24403794 0.83 PIM1 (0.45) RAB9ANPC1KMT2ANOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111269419-A Polyimide applicable to FOLED substrate and preparation method thereof 湖南工业大学 2020-06-12 CN disclosed
US-4250182-A Pharmaceutical composition containing acridone compounds and method of using same BURROUGHS WELLCOME CO. (US) 1981-02-10 US disclosed
US-4127573-A ANTIALLERGENS BURROUGHS WELLCOME CO. (US) 1978-11-28 US disclosed