Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL11343246 | 0.97 | PTGS2 (0.40) | PTGS2NLRP3POLBMAPK1HTT | |
| SCHEMBL11339692 | 0.93 | NLRP3 (0.46) | PTGS2NLRP3POLBMAPK1HTT | |
| SCHEMBL11339694 | 0.93 | NLRP3 (0.46) | PTGS2NLRP3POLBMAPK1HTT | |
| Glycine SCHEMBL11343520 | 0.92 | MAPK1 (0.41) | PTGS2NLRP3POLBMAPK1HTT | |
| Glycine SCHEMBL11341480 | 0.90 | NLRP3 (0.43) | PTGS2NLRP3POLBMAPK1HTT | |
| SCHEMBL11344719 | 0.90 | NLRP3 (0.43) | PTGS2NLRP3POLBMAPK1HTT | |
| SCHEMBL11344721 | 0.90 | NLRP3 (0.43) | PTGS2NLRP3POLBMAPK1HTT | |
| Glycine SCHEMBL11343095 | 0.89 | NLRP3 (0.48) | PTGS2NLRP3POLBMAPK1HTT | |
| Glycine SCHEMBL11339857 | 0.89 | PTGS2 (0.46) | PTGS2NLRP3POLBMAPK1HTT | |
| Glycine SCHEMBL11340116 | 0.89 | PTGS2 (0.42) | PTGS2NLRP3POLBMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4248886-A | Combating fungi with N-oxalyl-N-phenyl-aminoacids and esters thereof | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-03 | — | — | US | disclosed |