Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514618 | 0.82 | CYP3A4 (0.40) | APPCYP2C19CYP3A4AKR1C3AKR1C2 | |
| SCHEMBL19261796 | 0.82 | OPRM1 (0.53) | OPRM1SLC6A4SLC6A3OPRL1 | |
| SCHEMBL4515335 | 0.82 | OPRM1 (0.41) | APPCYP2C19CYP3A4CYP2C9OPRM1 | |
| SCHEMBL4503949 | 0.80 | OPRM1 (0.47) | APPCYP2C19CYP3A4AKR1C3AKR1C2 | |
| SCHEMBL4507377 | 0.80 | APP (0.47) | APPCYP2C19CYP3A4AKR1C3AKR1C2 | |
| SCHEMBL4826627 | 0.80 | OPRM1 (0.71) | OPRM1SLC6A4SLC6A3OPRL1 | |
| SCHEMBL4493375 | 0.80 | APP (0.43) | APPCYP2C19CYP3A4AKR1C3AKR1C2 | |
| SCHEMBL4503379 | 0.80 | OPRM1 (0.51) | APPCYP2C19CYP3A4AKR1C3AKR1C2 | |
| SCHEMBL12050459 | 0.78 | APP (0.63) | APPCYP2C19CYP3A4AKR1C3AKR1C2 | |
| SCHEMBL4504736 | 0.78 | AKR1C3 (0.43) | APPCYP2C19CYP3A4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076505-B2 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-13 | — | — | US | claimed |
| EP-2285765-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.p.A. (IT) | 2011-02-23 | — | — | EP | claimed |
| WO-2009149797-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-12-17 | — | — | WO | claimed |
| US-20090312426-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-12-17 | — | — | US | claimed |
| EP-2133322-A1 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-12-16 | — | — | EP | claimed |
| US-9056818-B2 | Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-16 | — | — | US | disclosed |
| EP-2462098-B1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMA SPA (IT) | 2013-10-23 | — | — | EP | disclosed |
| US-8076505-B2 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-13 | — | — | US | disclosed |
| EP-2285765-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.p.A. (IT) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009149797-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-12-17 | — | — | WO | disclosed |
| US-20090312426-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-12-17 | — | — | US | disclosed |
| EP-2133322-A1 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312426-A1 | PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CYP51A1, DHPS, CYP8B1 | APP 4370/4885CYP2C19 18/4885CYP3A4 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.