Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11244234 | 0.96 | CHEK2 (0.47) | CHEK2PDGFRBPDGFRAAURKATTK | |
| SCHEMBL3647945 | 0.82 | MAP4K4 (0.62) | CHEK2FYNMAP4K4METMAPT | |
| SCHEMBL17067696 | 0.81 | IDO1 (0.44) | MAP4K4PIK3CBAAK1 | |
| SCHEMBL14934141 | 0.80 | GAA (0.46) | CHEK2AURKATTKAURKBINCENP | |
| SCHEMBL11229832 | 0.80 | PDGFRB (0.56) | PDGFRBPDGFRAAURKATTKAURKB | |
| SCHEMBL1519413 | 0.80 | AURKA (0.61) | CHEK2PDGFRBPDGFRAAURKATTK | |
| SCHEMBL14934137 | 0.78 | JAK2 (0.48) | AURKATTKAURKBINCENPMAP4K4 | |
| Hydrochloric Acid SCHEMBL11240671 | 0.78 | AURKA (0.59) | CHEK2PDGFRBPDGFRAAURKATTK | |
| SCHEMBL14934094 | 0.77 | PDGFRB (0.49) | PDGFRBPDGFRAAURKATTKAURKB | |
| SCHEMBL14934142 | 0.77 | MKNK1 (0.45) | MAP4K4MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773631-B1 | PESTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2015-09-09 | — | — | EP | disclosed |
| WO-2013064519-A1 | PESTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-05-10 | — | — | WO | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |