Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934137 | 0.82 | JAK2 (0.48) | CYP11B2CYP11B1MAP4K4CYP1A2KCNH2 | |
| SCHEMBL21744554 | 0.78 | MKNK1 (0.55) | MKNK1MKNK2CYP11B2CYP11B1MAP4K4 | |
| SCHEMBL14934167 | 0.77 | MKNK1 (0.41) | MKNK1MKNK2CYP11B2CYP11B1FGFR1 | |
| SCHEMBL11338752 | 0.77 | CHEK2 (0.49) | MAP4K4MET | |
| SCHEMBL30838764 | 0.77 | — | — | |
| SCHEMBL27957344 | 0.77 | PLAU (0.47) | MAP4K4CYP1A2KCNH2MINK1TNIK | |
| SCHEMBL120637 | 0.77 | — | — | |
| SCHEMBL28107568 | 0.77 | CYP2A6 (0.56) | MKNK1MKNK2MAP4K4CYP1A2JAK2 | |
| SCHEMBL16826233 | 0.76 | PIK3CD (0.61) | MKNK1MKNK2CYP11B2CYP11B1MAP4K4 | |
| SCHEMBL3647945 | 0.74 | MAP4K4 (0.62) | MKNK1MKNK2MAP4K4METJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773631-B1 | PESTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2015-09-09 | — | — | EP | disclosed |
| WO-2013064519-A1 | PESTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-05-10 | — | — | WO | disclosed |