Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.42 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP3 | Q9H4L4 | 1/20 | 0.42 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL8423206 | 0.92 | MYC (0.43) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Ethylamine SCHEMBL7984887 | 0.92 | RAPGEF4 (0.47) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Hydroxyamine SCHEMBL8185329 | 0.90 | MYC (0.50) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Hydrazine SCHEMBL27884457 | 0.90 | MYC (0.50) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| SCHEMBL1748 | 0.89 | MYC (0.53) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| SCHEMBL29392580 | 0.89 | MYC (0.53) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Butylamine SCHEMBL6670622 | 0.88 | ALDH1A1 (0.44) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| SCHEMBL1557256 | 0.88 | SUMO2 (0.40) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| SCHEMBL10492882 | 0.88 | MYC (0.48) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL8126703 | 0.87 | MYC (0.52) | MYCRAPGEF4SUMO2SUMO1SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4254133-A | MITICIDE | CIBA-GEIGY CORPORATION (US) | 1981-03-03 | — | — | US | disclosed |
| US-4018765-A | HETEROCYCLIC | HOFFMANN-LA ROCHE INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-3931217-A | ANALGESIC, PSYCHOSTIMULANT | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |