Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134421 | 0.91 | OPRM1 (0.37) | OPRM1OPRL1L3MBTL3L3MBTL1 | |
| SCHEMBL1134306 | 0.83 | OPRM1 (0.35) | OPRM1OPRL1L3MBTL3L3MBTL1 | |
| SCHEMBL4352452 | 0.79 | OPRL1 (0.49) | OPRM1OPRL1 | |
| SCHEMBL28791711 | 0.77 | OPRM1 (0.38) | OPRM1OPRL1 | |
| SCHEMBL1134266 | 0.72 | — | — | |
| SCHEMBL1134321 | 0.72 | OPRM1 (0.31) | OPRM1OPRL1 | |
| SCHEMBL4350703 | 0.70 | OPRM1 (0.48) | OPRM1OPRL1 | |
| SCHEMBL13622840 | 0.69 | OPRL1 (0.45) | OPRM1OPRL1 | |
| SCHEMBL27814846 | 0.67 | OPRM1 (0.36) | OPRM1OPRL1 | |
| SCHEMBL12064423 | 0.63 | CYP1A2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285798-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | AstraZeneca AB (SE) | 2011-02-23 | — | — | EP | claimed |
| WO-2009136850-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | WO | claimed |
| EP-2285798-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | AstraZeneca AB (SE) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009136850-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | WO | disclosed |