Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TLR4 | O00206 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PPM1B | O75688 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12606807 | 0.89 | TLR4 (0.52) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL321283 | 0.89 | TLR4 (0.52) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2470785 | 0.87 | TLR4 (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL276016 | 0.87 | TLR4 (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL6949775 | 0.86 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| Ethylene SCHEMBL10579767 | 0.85 | TLR4 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4471152 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7392059 | 0.85 | TLR4 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL28368812 | 0.85 | TLR4 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7733726 | 0.85 | TLR4 (0.50) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288610-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | Incyte Corporation (US) | 2011-03-02 | — | — | EP | disclosed |
| EP-2285798-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | AstraZeneca AB (SE) | 2011-02-23 | — | — | EP | disclosed |
| EP-2209771-A1 | CYCLOBUTYL CARBOXYLIC ACID DERIVATIVES | Pfizer, Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009136850-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009114512-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2009-09-17 | — | — | WO | disclosed |
| WO-2009060278-A1 | CYCLOBUTYL CARBOXYLIC ACID DERIVATIVES | PFIZER INC. (US) | 2009-05-14 | — | — | WO | disclosed |