Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11340745 | 0.85 | EP300 (0.42) | DHODHHAO1EP300CREBBPMAPT | |
| SCHEMBL11334107 | 0.85 | MEN1 (0.49) | DHODHHAO1MEN1KMT2ACSNK2A1 | |
| SCHEMBL22608327 | 0.82 | MEN1 (0.46) | DHODHHAO1BRD4CREBBPMEN1 | |
| SCHEMBL11333461 | 0.79 | SMN1; SMN2 (0.53) | DHODHMAPTMEN1ALDH1A1GAA | |
| SCHEMBL22608750 | 0.79 | CSNK2A1 (0.41) | DHODHHAO1MAPTMEN1KMT2A | |
| SCHEMBL22608312 | 0.79 | CSNK2A1 (0.45) | HAO1MEN1GAAKMT2ACSNK2A1 | |
| SCHEMBL22608548 | 0.79 | KMO (0.47) | MAPTMEN1KMT2ALMNAKDR | |
| SCHEMBL22608538 | 0.78 | DHODH (0.55) | DHODHHAO1MAPTMEN1KMT2A | |
| SCHEMBL22608238 | 0.78 | KIF11 (0.44) | DHODHBRD4CREBBPMEN1KMT2A | |
| SCHEMBL22608153 | 0.77 | KMO (0.43) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002562-B1 | TRIAZOLO-QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1981-05-20 | — | — | EP | disclosed |
| US-4223032-A | BRONCHODILATOR AGENTS | BEECHAM GROUP LIMITED (GB) | 1980-09-16 | — | — | US | disclosed |
| EP-0002562-A1 | Triazolo-quinoline derivatives, processes for their preparation and their pharmaceutical use | BEECHAM GROUP PLC (GB) | 1979-06-27 | — | — | EP | disclosed |