Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | CD40 | P25942 | 3/20 | 0.38 |
| ▸ | CD40LG | P29965 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11341048 | 0.86 | MAPK14 (0.43) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL11419247 | 0.84 | HPSE (0.39) | MAPK14HPSEMAPK13MAPK12MAPK11 | |
| SCHEMBL11342303 | 0.84 | APEX1 (0.43) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL11347743 | 0.82 | MAPK14 (0.44) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL11352045 | 0.82 | MEN1 (0.42) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL10823511 | 0.82 | TTR (0.44) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL11342677 | 0.82 | ENPP2 (0.42) | MAPK14HPSEMAPK13MAPK12MAPK11 | |
| SCHEMBL11346496 | 0.82 | HPSE (0.47) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL11340801 | 0.82 | HPSE (0.47) | MAPK14TTRFABP4CCNA2CDK2 | |
| SCHEMBL11347922 | 0.80 | APEX1 (0.41) | MAPK14HPSEMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |