Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11711058 | 0.90 | ADORA2A (0.51) | ALDH1A1TDP1MEN1KMT2AKDR | |
| SCHEMBL11707608 | 0.87 | ALDH1A1 (0.52) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11709927 | 0.83 | ADORA2A (0.56) | ALDH1A1CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL12112372 | 0.82 | CHEK1 (0.61) | ALDH1A1TDP1MEN1KMT2ACHEK1 | |
| SCHEMBL13108710 | 0.80 | ALDH1A1 (0.85) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11467203 | 0.79 | MAPT (0.44) | ALDH1A1MEN1KMT2ACHEK1ABL1 | |
| Anitrazafen SCHEMBL30901204 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 | |
| Anitrazafen SCHEMBL43419 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5215665 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10817240 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4018923-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | claimed |
| US-4013654-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | claimed |
| EP-3019874-B1 | COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14 | TRANSLATIONAL GENOMICS RES INST (US) | 2019-08-21 | — | — | EP | disclosed |
| US-4251527-A | ANTIINFLAMMATORY AGENTS | DIAMOND SHAMROCK CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| US-4018923-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-4013654-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | disclosed |