SCHEMBL12112372

SCHEMBL12112372

Cc1nnc(-c2ccccc2)c(-c2ccccc2)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.61
ABL1 P00519 1/20 0.61
PDGFRB P09619 1/20 0.61
PDGFRA P16234 1/20 0.61
FLT1 P17948 1/20 0.61
GRK5 P34947 1/20 0.61
KDR P35968 1/20 0.61
MAP2K2 P36507 1/20 0.61
CDK8 P49336 1/20 0.61
GSK3A P49840 1/20 0.61
GSK3B P49841 1/20 0.61
PRKX P51817 1/20 0.61
NEK2 P51955 1/20 0.61
LIMK1 P53667 1/20 0.61
MAP2K1 Q02750 1/20 0.61
PRKCQ Q04759 1/20 0.61
MAP4K2 Q12851 1/20 0.61
DYRK1A Q13627 1/20 0.61
IKBKE Q14164 1/20 0.61
NTRK3 Q16288 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14665692 0.90 SMN1; SMN2 (0.66) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL17166610 0.84 CLK4 (0.55) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL11344932 0.82 ALDH1A1 (0.58) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL2658676 0.81 CLK4 (0.66) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL24689623 0.80 CHEK1 (0.47) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL11709927 0.78 ADORA2A (0.56) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL14665733 0.78 CHEK1 (0.49) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL11333718 0.77 ALDH1A1 (0.50) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL23009767 0.76 L3MBTL1 (0.56) CHEK1ABL1PDGFRBPDGFRAFLT1
SCHEMBL12388028 0.75 TDP1 (0.58) ALDH1A1ADORA2AADORA1NPSR1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4243101-A1 ORGANIC LIGHT-EMITTING DEVICE Lg Chem, Ltd. (KR) 2023-09-13 EP disclosed
EP-4242205-A1 NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME Lg Chem, Ltd. (KR) 2023-09-13 EP disclosed
WO-2022191488-A1 ORGANIC LIGHT-EMITTING DEVICE 주식회사 엘지화학 2022-09-15 WO disclosed
WO-2022191681-A1 NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME 주식회사 엘지화학 2022-09-15 WO disclosed
US-8053573-B2 Monomer 5, 6-diphenyl-1.2.4-traizinic derivatives and the use thereof PIERRE FABRE DERMO-COSMETIQUE (FR) 2011-11-08 US disclosed
EP-2107122-A1 Protease detection material, set of protease detection materials, and method for measuring protease FUJIFILM Corporation (JP) 2009-10-07 EP disclosed
US-20080299055-A1 Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof PIERRE FABRE DERMO-COSMETIQUE (FR) 2008-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080299055-A1 Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof POT1, TELO2, CLIC1 CHEK1 168/4885ABL1 1085/4885PDGFRB 629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.