Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823254 | 0.80 | MCL1 (0.51) | MCL1KDM4EHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL27603485 | 0.76 | MAOB (0.64) | MCL1KDM4EHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL10015552 | 0.75 | CYP1A2 (0.50) | KDM4EHPGDALDH1A1HSD17B10CYP1A2 | |
| Ammonia Solution, Strong SCHEMBL29137499 | 0.75 | CYP1A2 (0.55) | KDM4EHPGDALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL11335559 | 0.74 | CYP1A2 (0.46) | MCL1KDM4EHPGDTTRALDH1A1 | |
| SCHEMBL11465569 | 0.74 | KDM4E (0.46) | MCL1KDM4EHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL31389208 | 0.72 | CYP1A2 (0.58) | KDM4EHPGDALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL128319 | 0.72 | CYP1A2 (0.58) | KDM4EHPGDALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL28137300 | 0.72 | CYP1A2 (0.43) | MCL1KDM4EHPGDL3MBTL1TTR | |
| SCHEMBL9070324 | 0.71 | GPR35 (0.51) | KDM4EALDH1A1GPR35POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4259338-A | Benzofuranyl-tetrahydropyridines and -piperidines, their acid addition salts and antidepressant preparations thereof | CIBA-GEIGY CORPORATION (US) | 1981-03-31 | — | — | US | disclosed |
| EP-0006524-A1 | Tetrahydropyridine and tetrahydropiperidine derivatives, their acid addition salts, processes for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-01-09 | — | — | EP | disclosed |