Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 3/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | ENTPD3 | O75355 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | CBX7 | O95931 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10905295 | 0.93 | PPARG (0.41) | CYP1A2MAPTKMT2AHSD17B10PPARG | |
| SCHEMBL11347713 | 0.91 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3HPSEPRMT1 | |
| SCHEMBL11345079 | 0.89 | HPSE (0.47) | KCNJ6KCNJ5KCNJ3HPSEPRMT1 | |
| SCHEMBL11337824 | 0.85 | HPSE (0.45) | KCNJ6KCNJ5KCNJ3HPSEPRMT1 | |
| SCHEMBL11430487 | 0.85 | HPSE (0.43) | KCNJ6KCNJ5KCNJ3HPSEPRMT1 | |
| SCHEMBL11338996 | 0.84 | CA12 (0.43) | KCNJ6KCNJ5KCNJ3PRMT1MEN1 | |
| SCHEMBL10908768 | 0.84 | PPARG (0.41) | CYP1A2MAPTKMT2AHSD17B10PPARG | |
| SCHEMBL10907522 | 0.83 | HPSE (0.41) | HPSEPRMT1MEN1ENPP3ENTPD3 | |
| SCHEMBL11355263 | 0.82 | TIMP3 (0.54) | HPSEPRMT1MEN1USP2TIMP3 | |
| SCHEMBL10823457 | 0.82 | IDH1 (0.56) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |