Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 5/20 | 0.54 |
| ▸ | CD40 | P25942 | 2/20 | 0.50 |
| ▸ | CD40LG | P29965 | 2/20 | 0.50 |
| ▸ | FGF1 | P05230 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 2/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907534 | 0.93 | CD40 (0.50) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11344786 | 0.90 | TIMP3 (0.54) | TIMP3CD40CD40LGFGF1SIRT1 | |
| SCHEMBL11343207 | 0.88 | KMT2A (0.58) | TIMP3SIRT1MEN1USP2ALDH1A1 | |
| SCHEMBL11205429 | 0.86 | TIMP3 (0.56) | TIMP3CD40CD40LGFGF1SIRT1 | |
| SCHEMBL11427596 | 0.86 | HDAC1 (0.48) | CD40CD40LGMEN1ALDH1A1KMT2A | |
| SCHEMBL11348250 | 0.83 | HPSE (0.46) | TIMP3CD40CD40LGSIRT1MEN1 | |
| SCHEMBL11345990 | 0.83 | FGF1 (0.55) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11339195 | 0.82 | TIMP3 (0.48) | TIMP3CD40CD40LGFGF1SIRT1 | |
| SCHEMBL10907563 | 0.82 | CD40 (0.50) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11345504 | 0.82 | KCNJ6 (0.42) | TIMP3SIRT1MEN1USP2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |