Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMO | O15229 | 2/20 | 0.32 |
| ▸ | BCKDK | O14874 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11359829 | 0.86 | PARP10 (0.44) | PARP15PARP2TNKS2POLBSMN1; SMN2 | |
| SCHEMBL11418009 | 0.86 | KDM4E (0.36) | SMN1; SMN2PDE11AMAPTRAB9ANPC1 | |
| SCHEMBL11346930 | 0.84 | ALDH1A1 (0.47) | PARP15PARP2TNKS2SMN1; SMN2PDE11A | |
| SCHEMBL11419156 | 0.83 | NPC1 (0.33) | PARP2SMN1; SMN2PDE11AMAPTRAB9A | |
| SCHEMBL11409814 | 0.83 | CYP2C19 (0.33) | SMN1; SMN2PDE11AMAPTRAB9ANPC1 | |
| SCHEMBL11345987 | 0.83 | PARP15 (0.39) | PARP15PARP2TNKS2SMN1; SMN2PDE11A | |
| SCHEMBL11346879 | 0.83 | PDE1B (0.41) | POLBSMN1; SMN2PDE11AMAPTRAB9A | |
| SCHEMBL11347014 | 0.81 | SMN1; SMN2 (0.39) | PARP15PARP2TNKS2POLBSMN1; SMN2 | |
| SCHEMBL11595245 | 0.81 | NPC1 (0.41) | RAB9ANPC1 | |
| SCHEMBL11352934 | 0.80 | STING1 (0.33) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005154-B1 | 1-OXO-1H-PYRIMIDO (6,1-B) BENZOTHIAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-11-25 | — | — | EP | disclosed |
| EP-0005154-A1 | 1-Oxo-1H-pyrimido (6,1-b) benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing them | Roche Diagnostics GmbH (DE) | 1979-11-14 | — | — | EP | disclosed |