Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BCKDK | O14874 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11478388 | 0.86 | PARP10 (0.39) | SMN1; SMN2PARP15TNKS2PARP2POLB | |
| SCHEMBL11359826 | 0.85 | PARP10 (0.47) | SMN1; SMN2PARP15TNKS2PARP2POLB | |
| SCHEMBL11347017 | 0.81 | PARP15 (0.36) | SMN1; SMN2PARP15TNKS2PARP2POLB | |
| SCHEMBL11489038 | 0.81 | PARP15 (0.41) | SMN1; SMN2PARP15TNKS2PARP2POLB | |
| SCHEMBL11351095 | 0.81 | TP53 (0.48) | SMN1; SMN2PARP15TNKS2PARP2POLB | |
| SCHEMBL11409809 | 0.81 | TDP1 (0.36) | TP53KMT2ARAB9ANPC1CA1 | |
| SCHEMBL11356753 | 0.81 | PDE1B (0.44) | SMN1; SMN2POLBALDH1A1TP53RAB9A | |
| SCHEMBL11346661 | 0.80 | PDE11A (0.53) | SMN1; SMN2POLBALDH1A1TP53TSHR | |
| SCHEMBL11475165 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2PARP15TNKS2PARP2RXFP1 | |
| SCHEMBL11363546 | 0.74 | KDM4E (0.41) | SMN1; SMN2PARP15TNKS2PARP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005154-B1 | 1-OXO-1H-PYRIMIDO (6,1-B) BENZOTHIAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-11-25 | — | — | EP | disclosed |
| US-4232024-A | ANTIALLERGENS | BOEHRINGER MANNHEIM GMBH (DE) | 1980-11-04 | — | — | US | disclosed |
| EP-0005154-A1 | 1-Oxo-1H-pyrimido (6,1-b) benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing them | Roche Diagnostics GmbH (DE) | 1979-11-14 | — | — | EP | disclosed |