SCHEMBL11347331

SCHEMBL11347331

CCCCC(C)Nc1ccc(Cl)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 9/20 0.39
CCR4 P51679 4/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
ALDH1A1 P00352 1/20 0.39
TP53 P04637 1/20 0.39
HSP90AA1 P07900 1/20 0.39
CYP3A4 P08684 1/20 0.39
THRB P10828 1/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
CASP1 P29466 1/20 0.39
HIF1A Q16665 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ABL1 P00519 1/20 0.37
NPC1 O15118 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11345753 0.85 ALDH1A1 (0.42) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL11338196 0.81 ALDH1A1 (0.41) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL2722703 0.79 ALDH1A1 (0.60) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL28293706 0.76 ALDH1A1 (0.52) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL20746918 0.76 ALDH1A1 (0.39) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL12368476 0.76 TDP1 (0.41) S1PR1ALDH1A1CYP3A4THRBALOX15
SCHEMBL10395364 0.75 ALDH1A1 (0.45) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4
SCHEMBL11346318 0.75 S1PR1 (0.39) S1PR1SMN1; SMN2ALDH1A1TP53HSP90AA1
SCHEMBL6466532 0.74 CCR4 (0.35) CCR4SMN1; SMN2ALDH1A1TP53HSP90AA1
SCHEMBL11442419 0.74 ALDH1A1 (0.58) SMN1; SMN2ALDH1A1TP53HSP90AA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4261926-A REACTION WITH KETONE IN PRESENCE OF PLATINUM HYDROGENATION CATALYST AND A PROMOTER ACID AMERICAN CYANAMID COMPANY (US) 1981-04-14 US disclosed