Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 5/20 | 0.60 |
| ▸ | FGF1 | P05230 | 1/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.53 |
| ▸ | F11 | P03951 | 2/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11344456 | 0.96 | TIMP3 (0.58) | TIMP3FGF1PRMT1F11CASP6 | |
| SCHEMBL10908164 | 0.93 | TIMP3 (0.51) | TIMP3FGF1PRMT1F11CASP6 | |
| SCHEMBL10905317 | 0.89 | TIMP3 (0.50) | TIMP3FGF1PRMT1F11CASP6 | |
| SCHEMBL11342408 | 0.88 | TIMP3 (0.62) | TIMP3FGF1PRMT1HPSEKMT2A | |
| SCHEMBL11436818 | 0.88 | CASP6 (0.63) | TIMP3PRMT1CASP6CTDSP1CA1 | |
| SCHEMBL11339145 | 0.86 | TIMP3 (0.58) | TIMP3FGF1PRMT1F11CASP6 | |
| SCHEMBL11344033 | 0.86 | HPSE (0.48) | TIMP3FGF1PRMT1CASP6CTDSP1 | |
| SCHEMBL11437659 | 0.84 | MAPT (0.62) | CASP6CTDSP1CA1CA2KMT2A | |
| SCHEMBL11351829 | 0.84 | TIMP3 (0.58) | TIMP3FGF1PRMT1F11CASP6 | |
| SCHEMBL11343939 | 0.83 | RECQL (0.62) | TIMP3PRMT1HPSEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |