Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 1.00 |
| ▸ | CXCL12 | P48061 | 2/20 | 1.00 |
| ▸ | F3 | P13726 | 2/20 | 0.82 |
| ▸ | MAOA | P21397 | 5/20 | 0.73 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.69 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.69 |
| ▸ | RELA | Q04206 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630034 | 1.00 | MAOB (1.00) | MAOBCXCL12F3MAOACYP1B1 | |
| SCHEMBL25221687 | 1.00 | MAOB (1.00) | MAOBCXCL12F3MAOACYP1B1 | |
| SCHEMBL11348180 | 1.00 | MAOB (1.00) | MAOBCXCL12F3MAOACYP1B1 | |
| SCHEMBL25201115 | 1.00 | MAOB (1.00) | MAOBCXCL12F3MAOACYP1B1 | |
| SCHEMBL9630031 | 1.00 | MAOB (1.00) | MAOBCXCL12F3MAOACYP1B1 | |
| 4',4-Dichlorochalcone SCHEMBL659211 | 0.93 | MAOB (0.86) | MAOBCXCL12F3MAOACYP1B1 | |
| 4',4-Dichlorochalcone SCHEMBL659210 | 0.93 | MAOB (0.86) | MAOBCXCL12F3MAOACYP1B1 | |
| 4',4-Dichlorochalcone SCHEMBL11819262 | 0.91 | MAOB (0.83) | MAOBCXCL12F3MAOACYP1B1 | |
| 4',4-Dichlorochalcone SCHEMBL11819608 | 0.91 | MAOB (0.83) | MAOBCXCL12F3MAOACYP1B1 | |
| 4',4-Dichlorochalcone SCHEMBL11819257 | 0.91 | MAOB (0.83) | MAOBCXCL12F3MAOACYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217461-B | Chalcone derivative containing indole structure and preparation method and application thereof | 贵州大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-116283789-B | Pyridazine-containing chalcone derivative and preparation method and application thereof | 贵州大学 | 2024-09-03 | — | — | CN | disclosed |
| CN-116120256-B | Chalcone compound containing thiazole oxime ether and preparation method and application thereof | 贵州大学 | 2024-05-24 | — | — | CN | disclosed |
| CN-116283789-A | Pyridazine-containing chalcone derivative and preparation method and application thereof | 贵州大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-116217461-A | Chalcone derivative containing indole structure and preparation method and application thereof | 贵州大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-116120256-A | Chalcone compound containing thiazole oxime ether and preparation method and application thereof | 贵州大学 | 2023-05-16 | — | — | CN | disclosed |
| CN-109293616-B | Coumarin-containing chalcone derivatives, and preparation method and application thereof | 贵州大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-109251186-B | Chalcone derivative containing benzothiazole, and preparation method and application thereof | 贵州大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-109265332-B | Polyhydroxy chalcone compound and application thereof | 北京理工大学 | 2020-11-13 | — | — | CN | disclosed |
| US-9512087-B2 | Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation | COUNCIL FOR SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-12-06 | — | — | US | disclosed |
| EP-2721014-B1 | HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION | FDC LTD (IN) | 2016-10-26 | — | — | EP | disclosed |
| US-20130303579-A1 | HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-11-14 | — | — | US | disclosed |
| US-4279930-A | Process for treating inflammation | THE UPJOHN COMPANY (US) | 1981-07-21 | — | — | US | disclosed |
| US-3931152-A | ANTITUBERCULAR | AMERICAN CYANAMID COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303579-A1 | HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION | ERG28, CYP51A1, CYP2F1 | MAOB 1679/4885CXCL12 979/4885F3 671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.