4',4-Dichlorochalcone

4',4-Dichlorochalcone

SCHEMBL659210

O=C(/C=C/c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.86
CXCL12 P48061 2/20 0.86
MAOA P21397 3/20 0.83
CYP1B1 Q16678 1/20 0.82
F3 P13726 1/20 0.68
CYP1A2 P05177 1/20 0.67
MAPT P10636 1/20 0.66
TNFRSF1A P19438 1/20 0.66
ABCG2 Q9UNQ0 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4',4-Dichlorochalcone SCHEMBL659211 1.00 MAOB (0.86) MAOBCXCL12MAOACYP1B1F3
4',4-Dichlorochalcone SCHEMBL11819608 0.98 MAOB (0.83) MAOBCXCL12MAOACYP1B1F3
4',4-Dichlorochalcone SCHEMBL11819602 0.98 MAOB (0.83) MAOBCXCL12MAOACYP1B1F3
4',4-Dichlorochalcone SCHEMBL11819262 0.98 MAOB (0.83) MAOBCXCL12MAOACYP1B1F3
4',4-Dichlorochalcone SCHEMBL11819257 0.98 MAOB (0.83) MAOBCXCL12MAOACYP1B1F3
SCHEMBL25221687 0.93 MAOB (1.00) MAOBCXCL12MAOACYP1B1F3
SCHEMBL25202083 0.93 MAOB (0.77) MAOBCXCL12MAOACYP1B1F3
SCHEMBL11348184 0.93 MAOB (1.00) MAOBCXCL12MAOACYP1B1F3
SCHEMBL25190973 0.93 MAOB (0.77) MAOBCXCL12MAOACYP1B1F3
SCHEMBL11486409 0.93 MAOB (0.77) MAOBCXCL12MAOACYP1B1F3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062385-A1 ORGANIC COMPOUND SEMICONDUCTOR ENERGY LAB (JP) 2026-03-05 US disclosed
CN-115368268-B Method for efficiently preparing azo compound and application thereof 大连理工大学 2023-11-17 CN disclosed
US-11661407-B2 Process for the preparation of pyrylium salts COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2023-05-30 US disclosed
CN-115368268-A Method for efficiently preparing azo compound and application thereof 大连理工大学 2022-11-22 CN disclosed
US-20210400997-A1 APPLICATIONS OF DIPHENYLPROPENONE COMPOUND IN PREPARING ANIMAL FEED ADDITIVE OR ANIMAL FEED PENG, Xianfeng (CN) 2021-12-30 US disclosed
EP-3874964-A1 APPLICATIONS OF DIPHENYLPROPENONE COMPOUND IN PREPARING ANIMAL FEED ADDITIVE OR ANIMAL FEED Peng, Xianfeng (CN) 2021-09-08 EP disclosed
US-20210087158-A1 A PROCESS FOR THE PREPARATION OF PYRYLIUM SALTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2021-03-25 US disclosed
EP-2349999-B1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIV SAARLAND (DE) 2016-01-27 EP disclosed
US-8912186-B2 Allosteric protein kinase modulators UNIVERSITAET DES SAARLANDES (DE) 2014-12-16 US disclosed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 US disclosed
US-5360935-A From phenylmethanesulfonyl fluorides and phenylacyl bromides, phase transfer agent, base, solvent NIHON BAYER AGROCHEM K.K. (JP) 1994-11-01 US disclosed
EP-0540604-A1 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS Aventis Pharma S.A. (FR) 1993-05-12 EP disclosed
EP-0534249-A2 Process for the preparation of 3-phenyl-2-propenones NIHON BAYER AGROCHEM K.K. (JP) 1993-03-31 EP disclosed
WO-1992001675-A2 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS RHONE-POULENC RORER S.A. (FR) 1992-02-06 WO disclosed
US-4584008-A FUNGICIDES AND PLANT GROWTH REGULATORS CHEVRON RESEARCH COMPANY (US) 1986-04-22 US disclosed
EP-0102163-A1 Triazole derivatives and compositions containing the same CHEVRON RESEARCH COMPANY (US) 1984-03-07 EP disclosed
US-4095026-A PYRAZOLINE COMPOUNDS HAVING INSECTICIDAL ACTIVITY U.S. PHILIPS CORPORATION (US) 1978-06-13 US disclosed
US-4010271-A NOVEL PYRAZOLINE COMPOUNDS HAVING INSECTICIDAL ACTIVITY U.S. PHILIPS CORPORATION (US) 1977-03-01 US disclosed
US-3991073-A Pyrazoline compounds having insecticidal activity U.S. PHILIPS CORPORATION (US) 1976-11-09 US disclosed
US-3931152-A ANTITUBERCULAR AMERICAN CYANAMID COMPANY (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210087158-A1 A PROCESS FOR THE PREPARATION OF PYRYLIUM SALTS IPO5, SF3B5, CYP4F11 MAOB 2307/4885CXCL12 3140/4885MAOA 3394/4885
US-20260062385-A1 ORGANIC COMPOUND LAS1L, CCNL2, CCNA1 MAOB 1885/4885CXCL12 1195/4885MAOA 2046/4885
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB MAOB 4512/4885CXCL12 3504/4885MAOA 4177/4885
US-11661407-B2 Process for the preparation of pyrylium salts SF3B5, IPO5, CYP4F11 MAOB 2613/4885CXCL12 3354/4885MAOA 3764/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.