Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 8/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1134854 | 0.98 | GSK3B (0.49) | GSK3BCES1CHKATSHRNR3C2 | |
| SCHEMBL5213200 | 0.89 | CHKA (0.55) | CES1CHKATSHRLMNAHPGD | |
| Hydrochloric Acid SCHEMBL6414496 | 0.87 | CHKA (0.53) | CES1CHKATSHRCSF1RLMNA | |
| Ethane SCHEMBL6986774 | 0.87 | CHKA (0.53) | CES1CHKATSHRLMNAHPGD | |
| SCHEMBL7155149 | 0.87 | NR3C2 (0.56) | GSK3BCES1CHKATSHRNR3C2 | |
| SCHEMBL20385081 | 0.84 | MEN1 (0.52) | GSK3BCES1CHKANR3C2LMNA | |
| SCHEMBL31886 | 0.84 | MEN1 (0.52) | GSK3BCES1CHKANR3C2LMNA | |
| SCHEMBL22931682 | 0.84 | MEN1 (0.52) | GSK3BCES1CHKANR3C2LMNA | |
| SCHEMBL6567354 | 0.84 | MEN1 (0.52) | GSK3BCES1CHKANR3C2LMNA | |
| Benzene SCHEMBL14537401 | 0.84 | MEN1 (0.52) | GSK3BCES1CHKANR3C2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350031-B2 | Processes for the synthesis of levocetirizine and intermediates for use therein | CIPLA LIMITED (IN) | 2013-01-08 | — | — | US | claimed |
| CN-102046612-A | Processes for the synthesis of levocetirizine and intermediates for use therein | CIPLA LTD | 2011-05-04 | — | — | CN | claimed |
| EP-2307392-A2 | PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN | Cipla Limited (IN) | 2011-04-13 | — | — | EP | claimed |
| WO-2009147389-A2 | PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN | CIPLA LIMITED (IN) | 2009-12-10 | — | — | WO | claimed |
| EP-1963296-A2 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | Egis Gyógyszergyár Nyilvánosan Múködö Részvénytársaság (HU) | 2008-09-03 | — | — | EP | claimed |
| WO-2007066163-A2 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | Egis Gyógyszergyár Nyilvanosan Mukodo Reszvenytarsasag (HU) | 2007-06-14 | — | — | WO | claimed |
| CN-110294713-A | A kind of preparation method of imidazoles methylamine like derivative | 西华大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-110294714-A | Imidazoles methylamine like derivative and its synthetic method with indoles amine -2,3- dioxygenase (IDO) inhibitor activity | 西华大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-103613567-A | Synthetic process for chlorcyclizine hydrochloride | JIAOZUO FURUITANG PHARMACEUTICAL CO LTD | 2014-03-05 | — | — | CN | disclosed |
| CN-102675017-A | Method for preparing chiral diaryl- substitute methylamine | HEBEI BRANT PHARMACEUTICAL CO LTD | 2012-09-19 | — | — | CN | disclosed |
| WO-2012101475-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ANTIHISTAMINIC DRUGS VIA A NOVEL CARBAMATE INTERMEDIATE | JUBILANT LIFE SCIENCES LIMITED (IN) | 2012-08-02 | — | — | WO | disclosed |
| US-20110251389-A1 | Process For Making N-(Diphenylmethyl)piperazines | ZHU JIE | 2011-10-13 | — | — | US | disclosed |
| US-7989623-B2 | Process for making n-(diphenylmethyl)piperazines | SYNTHON BV (NL) | 2011-08-02 | — | — | US | disclosed |
| US-7385058-B1 | Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2008-06-10 | — | — | US | disclosed |
| WO-2007066163-A2 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | Egis Gyógyszergyár Nyilvanosan Mukodo Reszvenytarsasag (HU) | 2007-06-14 | — | — | WO | disclosed |
| EP-0355351-B1 | Process for the preparation of amines | BAYER AG (DE) | 1993-11-10 | — | — | EP | disclosed |
| US-5011996-A | Process for the preparation of amines | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-30 | — | — | US | disclosed |
| EP-0355351-A2 | Process for the preparation of amines | BAYER AG (DE) | 1990-02-28 | — | — | EP | disclosed |
| US-4115413-A | ACID FREE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-19 | — | — | US | disclosed |
| US-4002631-A | HEAT-SENSITIVE COLOR FORMERS | HODOGAYA CHEMICAL CO., LTD. (JA) | 1977-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251389-A1 | Process For Making N-(Diphenylmethyl)piperazines | CYP51A1, CYP3A5, CYP4Z1 | GSK3B 2521/4885CES1 361/4885CHKA 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.