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Oxycodone

Oxycodone

SCHEMBL1134895

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Oxycodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 known ✓ P35372 8/20 1.00
▸ OPRD1 P41143 7/20 1.00
▸ OPRK1 P41145 6/20 0.98
▸ LMNA P02545 1/20 0.76
▸ BLM P54132 1/20 0.76
▸ ALDH1A1 P00352 1/20 0.74
▸ CYP3A4 P08684 1/20 0.74
▸ CYP2D6 P10635 1/20 0.74
▸ TSHR P16473 1/20 0.74
▸ HSD17B10 Q99714 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxycodone SCHEMBL15549172 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL2029375 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL30095 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL2029377 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL18395933 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL29372313 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL29789443 1.00 OPRM1 (1.00) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL14109977 0.99 OPRM1 (0.98) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL16667043 0.99 OPRM1 (0.98) OPRM1OPRD1OPRK1LMNABLM
Oxycodone SCHEMBL28884353 0.99 OPRM1 (0.98) OPRM1OPRD1OPRK1LMNABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2080514-B1 Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic PURDUE PHARMA LP (US) 2011-02-23 — — EP disclosed