Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxycodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 7/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxycodone SCHEMBL15549172 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL1134895 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL30095 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL2029377 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL18395933 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL29372313 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL29789443 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL14109977 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL16667043 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1OPRK1LMNABLM | |
| Oxycodone SCHEMBL28884353 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1OPRK1LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263542-A1 | METHODS TO TREAT PAIN USING AN ALPHA-2 ADRENERGIC AGONIST AND AN ENDOTHELIN ANTAGONIST | ENGOGENX (US) | 2011-10-27 | — | — | US | disclosed |
| EP-2330903-A1 | METHODS TO TREAT PAIN USING AN ALPHA-2 ADRENERGIC AGONIST AND AN ENDOTHELIN ANTAGONIST | Endogenx, Inc. (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010014076-A1 | METHODS TO TREAT PAIN USING AN ALPHA-2 ADRENERGIC AGONIST AND AN ENDOTHELIN ANTAGONIST | EndogenX, Inc. (US) | 2010-02-04 | — | — | WO | disclosed |
| US-20100022574-A1 | Methods to Treat Pain Using an Alpha-2 Adrenergic Agonist and an Endothelin Antagonist | EndogenX, Inc. (US) | 2010-01-28 | — | — | US | disclosed |