SCHEMBL11355488

SCHEMBL11355488

O=C(CBr)c1ccc(Cl)cc1OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 5/20 0.54
MRGPRX4 Q96LA9 3/20 0.50
MCL1 Q07820 1/20 0.49
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
MAOB P27338 1/20 0.48
LRRK2 Q5S007 2/20 0.47
KMT2A Q03164 1/20 0.47
FOLH1 Q04609 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4473413 0.86 MAOB (0.61) NPC1RAB9AMAOBKMT2AFOLH1
SCHEMBL3926335 0.85 PTGER1 (0.67) PTGER1MRGPRX4MCL1NPC1RAB9A
SCHEMBL1106974 0.84 PTGES (0.51) PTGER1MAOBLRRK2FOLH1
SCHEMBL31605214 0.84 PTGES (0.51) PTGER1MAOBLRRK2FOLH1
SCHEMBL31375951 0.84 PTGER1 (0.58) PTGER1MRGPRX4MCL1NPC1RAB9A
SCHEMBL4472145 0.83 MRGPRX4 (0.49) PTGER1MRGPRX4MCL1NPC1RAB9A
SCHEMBL21436822 0.83 MCL1 (0.55) PTGER1MRGPRX4MCL1MAOBFOLH1
SCHEMBL4481452 0.83 FFAR4 (0.51) PTGER1MRGPRX4NPC1MAOBLRRK2
SCHEMBL11357851 0.83 MAOB (0.61) PTGER1MRGPRX4MCL1MAOBLRRK2
SCHEMBL1425720 0.83 PTGER1 (0.56) PTGER1MRGPRX4MCL1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782999-B1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE GLACEUM INC (KR) 2023-05-10 EP disclosed
EP-3782999-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE Glaceum, Inc. (KR) 2021-02-24 EP disclosed
WO-2019194582-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE 주식회사 글라세움 2019-10-10 WO disclosed
US-4265903-A HYPOTENSIVE, ADRENOLYTIC BEIERSDORF AKTIENGESELLSCHAFT (DE) 1981-05-05 US disclosed