SCHEMBL11355877

SCHEMBL11355877

COc1ccc(C=CC(N)=O)c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.53
ALDH1A1 P00352 2/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
MAOB P27338 2/20 0.51
ABCG2 Q9UNQ0 2/20 0.51
LMNA P02545 2/20 0.50
HPGD P15428 1/20 0.50
JUN P05412 1/20 0.49
NFKB1 P19838 1/20 0.49
KDM4E B2RXH2 2/20 0.48
TNFRSF1A P19438 1/20 0.48
L3MBTL1 Q9Y468 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
ATM Q13315 1/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27173982 0.86 THRB (0.56) MAPTALDH1A1MEN1KMT2AMAOB
SCHEMBL8147548 0.83 MAPT (0.77) MAPTALDH1A1MEN1KMT2ALMNA
SCHEMBL20227828 0.83 MAPT (0.54) MAPTALDH1A1MEN1KMT2AABCG2
SCHEMBL7411020 0.83 MAPT (0.77) MAPTALDH1A1MEN1KMT2ALMNA
SCHEMBL4773932 0.82 MAOB (0.74) MAPTALDH1A1MAOBABCG2LMNA
SCHEMBL30632936 0.81 CA12 (0.57) MAPTALDH1A1MEN1KMT2AMAOB
SCHEMBL30560945 0.81 CA12 (0.57) MAPTALDH1A1MEN1KMT2AMAOB
SCHEMBL22398305 0.81 CA12 (0.57) MAPTALDH1A1MEN1KMT2AMAOB
SCHEMBL27846176 0.80 MAPT (0.73) MAPTALDH1A1MEN1KMT2AMAOB
SCHEMBL27846178 0.80 MAPT (0.73) MAPTALDH1A1MEN1KMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0001997-B1 ELECTRON BEAM-CURABLE PHOTORESIST LACQUERS BAYER AG (DE) 1981-02-11 EP disclosed
EP-0001997-A1 Electron beam-curable photoresist lacquers BAYER AG (DE) 1979-05-30 EP disclosed