Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11359449 | 1.00 | HTR2C (0.42) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL11356207 | 0.90 | HTR2A (0.42) | HTR2CHTR2AHTR2B | |
| SCHEMBL11356203 | 0.90 | HTR2A (0.42) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL11048637 | 0.89 | HTR2A (0.41) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL11048640 | 0.89 | HTR2A (0.41) | HTR2CHTR2AHTR2B | |
| SCHEMBL11368333 | 0.86 | HTR1A (0.39) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL11368331 | 0.86 | HTR1A (0.39) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL11052131 | 0.85 | SLC18A3 (0.43) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL11568676 | 0.85 | SLC18A3 (0.43) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL11052133 | 0.85 | SLC18A3 (0.43) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277404-A | INTERMEDIATES FOR TRANQUILIZERS | PFIZER INC. (US) | 1981-07-07 | — | — | US | disclosed |
| US-4267331-A | REDUCTIVE ALKYLATION OF A 5-PHENYL-2,3,4,4A,5,9B-HEXAHYDRO-1H-PYRIDO/4,3-B/INDOLE WITH A REDUCING AGENT AND A 2-HYDROXY-5- OR 6-PHENYLFURAN OR -PYRAN | PFIZER INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4252812-A | TRANQUILIZERS | PFIZER INC. (US) | 1981-02-24 | — | — | US | disclosed |
| US-4224329-A | TRANQUILIZERS | PFIZER INC. (US) | 1980-09-23 | — | — | US | disclosed |