Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893904 | 1.00 | SLC22A6 (0.57) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3371887 | 1.00 | SLC22A6 (0.57) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2227091 | 1.00 | SLC22A6 (0.57) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17204173 | 1.00 | SLC22A6 (0.57) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL30641549 | 1.00 | SLC22A6 (0.57) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL30972500 | 0.87 | — | — | |
| SCHEMBL374298 | 0.87 | — | — | |
| SCHEMBL1405707 | 0.87 | — | — | |
| SCHEMBL2687087 | 0.87 | — | — | |
| SCHEMBL6453593 | 0.87 | SLC22A6 (0.75) | SLC22A6GABRR1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118562779-A | Stable halohydrin dehalogenase freeze-dried powder preparation and application thereof | 浙江乐普药业股份有限公司 | 2024-08-30 | — | — | CN | claimed |
| CN-117625707-A | Biological preparation method of (2S, 4R) -4-hydroxytetrahydrofuran-2-tert-butyl acetate | 苏州华道生物药业股份有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-117089533-A | Recombinant carbonyl reductase, mutant, coding gene and application thereof | 浙江工业大学 | 2023-11-21 | — | — | CN | claimed |
| CN-114410599-B | Carbonyl reductase mutant and application thereof in preparation of rosuvastatin chiral intermediate | 浙江工业大学 | 2023-08-18 | — | — | CN | claimed |
| CN-114874181-A | Preparation method of rosuvastatin chiral side chain intermediate | 湖北迅达药业股份有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-113621589-A | Aldehyde ketone reductase KmAKR mutant, engineering bacteria and application thereof | 浙江工业大学 | 2021-11-09 | — | — | CN | claimed |
| CN-110423741-B | Carbonyl reductase-coenzyme NADP+Co-immobilized enzyme and preparation and application thereof | 浙江工业大学 | 2021-08-17 | — | — | CN | claimed |
| CN-109295119-B | Biocatalysis method for producing statin drug intermediate | 浙江宏元药业股份有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-107653238-B | Carbonyl reductase gene engineering bacterium immobilized cell and application thereof | 浙江工业大学 | 2021-05-11 | — | — | CN | claimed |
| CN-110387359-B | Carbonyl reductase mutant and application thereof | 湖州颐盛生物科技有限公司 | 2021-04-20 | — | — | CN | claimed |
| CN-106011094-B | Engineered ketoreductase polypeptide and method for preparing (3R,5S) -6-chloro-3, 5-dyhydroxyl hexanoic acid tert-butyl ester by using same | 苏州汉酶生物技术有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-107058251-B | Recombinant carbonyl reductase mutant, gene, vector, engineering bacterium and application thereof | 浙江工业大学 | 2020-10-09 | — | — | CN | claimed |
| US-10724008-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2020-07-28 | — | — | US | claimed |
| EP-3134519-B1 | KETOREDUCTASES | C LECTA GMBH (DE) | 2018-06-06 | — | — | EP | claimed |
| US-20170218345-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2017-08-03 | — | — | US | claimed |
| EP-3134519-A1 | KETOREDUCTASES | c-LEcta GmbH (DE) | 2017-03-01 | — | — | EP | claimed |
| WO-2015162064-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2015-10-29 | — | — | WO | claimed |
| US-6645746-B1 | Expression vector; transformants; E. coli; Candida; Bacillus; use of microorganisms to produce t-butyl(3R,5S)-6-chloro-3,5 -dihydroxyhexanoate, by enzymatic asymmetrical reduction, for drug, pesticide and HMG-CoA reductase inhibitor synthesis | KANEKA CORPORATION (JP) | 2003-11-11 | — | — | US | claimed |
| EP-1152054-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2001-11-07 | — | — | EP | claimed |
| CN-120485143-A | Carbonyl reductase mutant and application thereof in synthesizing statin drug intermediate | 浙江工业大学 | 2025-08-15 | — | — | CN | disclosed |
| CN-120060178-A | Alcohol dehydrogenase mutant composition and application thereof | 南京桦冠生物技术有限公司 | 2025-05-30 | — | — | CN | disclosed |
| CN-120060178-A | Alcohol dehydrogenase mutant composition and application thereof | 南京桦冠生物技术有限公司 | 2025-05-30 | — | — | CN | disclosed |
| CN-118562779-A | Stable halohydrin dehalogenase freeze-dried powder preparation and application thereof | 浙江乐普药业股份有限公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-118562779-A | Stable halohydrin dehalogenase freeze-dried powder preparation and application thereof | 浙江乐普药业股份有限公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-117904066-A | Recombinant carbonyl reductase mutant and application thereof in catalytic synthesis of chiral alcohol | 浙江工业大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-117625707-A | Biological preparation method of (2S, 4R) -4-hydroxytetrahydrofuran-2-tert-butyl acetate | 苏州华道生物药业股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117089533-A | Recombinant carbonyl reductase, mutant, coding gene and application thereof | 浙江工业大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-114181188-B | Non-solvation synthesis method of atorvastatin calcium intermediate | 江苏阿尔法药业股份有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114875081-A | Green industrial production method of rosuvastatin key intermediate | 湖北迅达药业股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-114874181-A | Preparation method of rosuvastatin chiral side chain intermediate | 湖北迅达药业股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-114181188-A | Non-solvation synthesis method of atorvastatin calcium intermediate | 江苏阿尔法药业股份有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-113621589-A | Aldehyde ketone reductase KmAKR mutant, engineering bacteria and application thereof | 浙江工业大学 | 2021-11-09 | — | — | CN | disclosed |
| CN-110423741-B | Carbonyl reductase-coenzyme NADP+Co-immobilized enzyme and preparation and application thereof | 浙江工业大学 | 2021-08-17 | — | — | CN | disclosed |
| CN-109295119-B | Biocatalysis method for producing statin drug intermediate | 浙江宏元药业股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-109295119-B | Biocatalysis method for producing statin drug intermediate | 浙江宏元药业股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-107653238-B | Carbonyl reductase gene engineering bacterium immobilized cell and application thereof | 浙江工业大学 | 2021-05-11 | — | — | CN | disclosed |
| CN-110387359-B | Carbonyl reductase mutant and application thereof | 湖州颐盛生物科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-110387359-B | Carbonyl reductase mutant and application thereof | 湖州颐盛生物科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-108486075-B | Recombinant carbonyl reductase mutant, gene, engineering bacterium and application thereof | 浙江工业大学 | 2020-11-13 | — | — | CN | disclosed |
| CN-106011094-B | Engineered ketoreductase polypeptide and method for preparing (3R,5S) -6-chloro-3, 5-dyhydroxyl hexanoic acid tert-butyl ester by using same | 苏州汉酶生物技术有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-107058251-B | Recombinant carbonyl reductase mutant, gene, vector, engineering bacterium and application thereof | 浙江工业大学 | 2020-10-09 | — | — | CN | disclosed |
| CN-108048438-B | Halohydrin dehalogenase mutant and application thereof | 浙江宏元药业股份有限公司 | 2020-08-18 | — | — | CN | disclosed |
| US-10724008-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2020-07-28 | — | — | US | disclosed |
| US-10093905-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2018-10-09 | — | — | US | disclosed |
| CN-108441523-A | Preparation method of tert-butyl (3R,5S) -6-chloro-3, 5-dihydroxyhexanoate | 南京工业大学 | 2018-08-24 | — | — | CN | disclosed |
| CN-108441523-A | Preparation method of tert-butyl (3R,5S) -6-chloro-3, 5-dihydroxyhexanoate | 南京工业大学 | 2018-08-24 | — | — | CN | disclosed |
| EP-3134519-B1 | KETOREDUCTASES | C LECTA GMBH (DE) | 2018-06-06 | — | — | EP | disclosed |
| US-20170218345-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| EP-2890810-B1 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2017-08-02 | — | — | EP | disclosed |
| EP-3134519-A1 | KETOREDUCTASES | c-LEcta GmbH (DE) | 2017-03-01 | — | — | EP | disclosed |
| US-9228214-B2 | Process for the enantioselective enzymatic reduction of hydroxy keto compounds | CAMBREX IEP GMBH (DE) | 2016-01-05 | — | — | US | disclosed |
| CN-105087684-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | LIANYUNGANG HONGYE CHEMICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-105087685-A | Method for synthesizing (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | LIANYUNGANG HONGYE CHEMICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-105087684-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | LIANYUNGANG HONGYE CHEMICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-105087685-A | Method for synthesizing (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | LIANYUNGANG HONGYE CHEMICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |
| WO-2015162064-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2015-10-29 | — | — | WO | disclosed |
| EP-2890810-A1 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES | Forschungszentrum Jülich GmbH (DE) | 2015-07-08 | — | — | EP | disclosed |
| CN-104726506-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | ENZYMEWORKS INC | 2015-06-24 | — | — | CN | disclosed |
| CN-104726506-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | ENZYMEWORKS INC | 2015-06-24 | — | — | CN | disclosed |
| US-20150152451-A1 | PROCESS FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXY KETO COMPOUNDS | CAMBREX IEP GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| CN-104651290-A | Engineering bacterium and application thereof in preparation of atorvastatin drug intermediate | UNIV ZHEJIANG | 2015-05-27 | — | — | CN | disclosed |
| US-8980592-B2 | Process for the enantioselective enzymatic reduction of hydroxy keto compounds | CAMBREX IEP GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| WO-2014203045-A1 | A NOVEL, GREEN AND COST EFFECTIVE PROCESS FOR SYNTHESIS OF TERT-BUTYL (3R,5S)-6-OXO-3,5-DIHYDROXY-3,5-O-ISOPROPYLIDENE-HEXANOATE | LUPIN LIMITED (IN) | 2014-12-24 | — | — | WO | disclosed |
| CN-104087546-A | Engineering bacteria and method for preparing tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | UNIV ZHEJIANG | 2014-10-08 | — | — | CN | disclosed |
| CN-104087546-A | Engineering bacteria and method for preparing tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | UNIV ZHEJIANG | 2014-10-08 | — | — | CN | disclosed |
| EP-2066788-B1 | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | CODEXIS INC (US) | 2014-07-23 | — | — | EP | disclosed |
| WO-2014032777-A1 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES | Forschungszentrum Jülich GmbH (DE) | 2014-03-06 | — | — | WO | disclosed |
| CN-103483195-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | Huanggang huayang pharmaceutical co ltd | 2014-01-01 | — | — | CN | disclosed |
| CN-103483195-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | Huanggang huayang pharmaceutical co ltd | 2014-01-01 | — | — | CN | disclosed |
| US-8617864-B2 | Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor | CODEXIS, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| WO-2013068917-A1 | PROCESSES FOR THE PRODUCTION OF A LACTONE STATIN INTERMEDIATE BY ENZYMATIC OXIDATION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2013-05-16 | — | — | WO | disclosed |
| WO-2013068917-A1 | PROCESSES FOR THE PRODUCTION OF A LACTONE STATIN INTERMEDIATE BY ENZYMATIC OXIDATION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2013-05-16 | — | — | WO | disclosed |
| US-20130040364-A1 | POLYNUCLEOTIDES ENCODING KETOREDUCTASES FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | CODEXIS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-8273547-B2 | Engineered ketoreductases and methods for producing stereoisomerically pure statins | CODEXIS, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8148324-B2 | Aldolases, nucleic acids encoding them; improving thermal stability of enzyme; biosynthesis of atorvastatin, rosuvastatin, fluvastatin starting from e.g. acetaldehyde and chloroacetaldehyde, using enzyme 2-deoxyribose-5-phosphate aldolase (DERA) to form pyran intermediate | VERENIUM CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110195465-A1 | Compositions and Methods for Producing Stereoisomerically Pure Statins and Synthetic Intermediates Therefor | CODEXIS, INC. (US) | 2011-08-11 | — | — | US | disclosed |
| EP-1963516-B1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GMBH (DE) | 2011-02-23 | — | — | EP | disclosed |
| EP-1619191-B1 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives | KANEKA CORP (JP) | 2010-10-27 | — | — | EP | disclosed |
| US-7807423-B2 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives | CODEXIS, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090221044-A1 | Process for the Enantioselective Enzymatic Reduction of Hydroxy Keto Compounds | IEP GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-2066788-A2 | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Codexis, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| US-20080289056-A1 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | VERENIUM CORPORATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080248539-A1 | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | CODEXIS, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| EP-1963516-A1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| US-7414119-B2 | Aldolases, nucleic acids encoding them and methods for making and using them | VERENIUM CORPORATION (US) | 2008-08-19 | — | — | US | disclosed |
| WO-2008042876-A2 | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | CODEXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |
| WO-2007137816-A1 | PROCESS FOR THE PREPARATION OF EPOXIDE INTERMEDIATES FOR PHARMACEUTICAL COMPOUNDS SUCH AS STATINS | DSM IP ASSETS B.V. (NL) | 2007-12-06 | — | — | WO | disclosed |
| EP-1394157-B1 | Process for the preparation of 3,5-dihydroxy substituted esters as intermediates for producing optically active 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) acetic acid dervatives | KANEKA CORP (JP) | 2007-10-17 | — | — | EP | disclosed |
| US-20070161094-A1 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives | CODEXIS, INC. (US) | 2007-07-12 | — | — | US | disclosed |
| WO-2007073875-A1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GMBH (DE) | 2007-07-05 | — | — | WO | disclosed |
| US-7132267-B2 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters | CODEXIS, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| EP-1625223-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | Diversa Corporation (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1619191-A2 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives | KANEKA CORPORATION (JP) | 2006-01-25 | — | — | EP | disclosed |
| US-20050153407-A1 | Chemoenzymatic methods for the synthesis of statins and stain intermediates | VERENIUM CORPORATION | 2005-07-14 | — | — | US | disclosed |
| US-6903225-B2 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives | KANEKA CORPORATION (JP) | 2005-06-07 | — | — | US | disclosed |
| EP-1152054-B1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2005-03-23 | — | — | EP | disclosed |
| EP-1152054-B1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2005-03-23 | — | — | EP | disclosed |
| US-20040214297-A1 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives | CODEXIS, INC. | 2004-10-28 | — | — | US | disclosed |
| EP-1024139-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-(6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL) ACETIC ACID DERIVATIVES | KANEKA CORP (JP) | 2004-05-12 | — | — | EP | disclosed |
| WO-2004027075-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STAIN INTERMEDIATES | DIVERSA CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |
| EP-1394157-A2 | Process for the preparation of 3,5-dihydroxy substituted esters as intermediates for producing optically active 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) acetic acid dervatives | KANEKA CORPORATION (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-6645746-B1 | Expression vector; transformants; E. coli; Candida; Bacillus; use of microorganisms to produce t-butyl(3R,5S)-6-chloro-3,5 -dihydroxyhexanoate, by enzymatic asymmetrical reduction, for drug, pesticide and HMG-CoA reductase inhibitor synthesis | KANEKA CORPORATION (JP) | 2003-11-11 | — | — | US | disclosed |
| US-6645746-B1 | Expression vector; transformants; E. coli; Candida; Bacillus; use of microorganisms to produce t-butyl(3R,5S)-6-chloro-3,5 -dihydroxyhexanoate, by enzymatic asymmetrical reduction, for drug, pesticide and HMG-CoA reductase inhibitor synthesis | KANEKA CORPORATION (JP) | 2003-11-11 | — | — | US | disclosed |
| EP-1077212-B1 | PROCESS FOR PRODUCING 6-CYANOMETHYL-1,3-DIOXANE-4-ACETIC ACID DERIVATIVES | KANEKA CORP (JP) | 2003-08-20 | — | — | EP | disclosed |
| US-20030040634-A1 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives | KANEKA CORPORATION (JP) | 2003-02-27 | — | — | US | disclosed |
| EP-1152054-A4 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-6472544-B1 | REACTING ACETIC ACID DERIVATIVE WITH AN ENOLATE, REDUCING WITH A MICROORGANISM, ACETALIZING IN PRESENCE OF ACID CATALYST THEN ALKALINE SAPONIFICATION; NO SPECIAL EQUIPMENT OR SUPER LOW TEMPERATURE REQUIRED; INEXPENSIVE STARTING MATERIALS | KANEKA CORPORATION (JP) | 2002-10-29 | — | — | US | disclosed |
| EP-1152054-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2001-11-07 | — | — | EP | disclosed |
| EP-1152054-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2001-11-07 | — | — | EP | disclosed |
| WO-2001040450-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORPORATION (JP) | 2001-06-07 | — | — | WO | disclosed |
| EP-1077212-A1 | PROCESS FOR PRODUCING 6-CYANOMETHYL-1,3-DIOXANE-4-ACETIC ACID DERIVATIVES | KANEKA CORPORATION (JP) | 2001-02-21 | — | — | EP | disclosed |
| EP-1024139-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2- 6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL]ACETIC ACID DERIVATIVES | KANEKA CORPORATION (JP) | 2000-08-02 | — | — | EP | disclosed |
| US-5594153-A | REACTING 6-HALO-3,5-DIHYDROXYHEXANOIC ACID OR DERIVATIVE THEREOF WITH DIETHER, KETONE OR UNSATURATED ETHER TO FORM 1,3-DIOXANE DERIVATIVE | E. R. SQUIBB & SONS, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5457227-A | Condensing halo-substituted hydroxy ester with acetic acid, acetate salt or ester in presence of condensation agent to produce halo-substituted hydroxy keto ester | E. R. SQUIBB & SONS, INC. (US) | 1995-10-10 | — | — | US | disclosed |
| US-5278313-A | Chemical condensation reaction | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5278313-A | Chemical condensation reaction | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040634-A1 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives | HAAO, APEH, AADAC | SLC22A6 2542/4885GABRR1 2963/4885LMNA 2150/4885 |
| US-20080248539-A1 | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | COASY, FAR1, HMGCR | SLC22A6 2136/4885GABRR1 724/4885LMNA 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.