Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367617 | 0.84 | CYP1A2 (0.66) | CYP1A2PBRM1HSD17B10TSHRMEN1 | |
| SCHEMBL11350233 | 0.82 | HSD17B10 (0.43) | CYP1A2PBRM1HSD17B10MEN1KMT2A | |
| SCHEMBL7426368 | 0.80 | CYP1A2 (1.00) | CYP1A2HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL11352311 | 0.74 | PBRM1 (0.43) | CYP1A2PBRM1HSD17B10MEN1KMT2A | |
| SCHEMBL11362107 | 0.73 | CYP1A2 (0.68) | CYP1A2HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL11366929 | 0.73 | CYP1A2 (0.68) | CYP1A2HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL13091488 | 0.71 | CYP1A2 (0.44) | CYP1A2MEN1KMT2AIDO1ALDH1A1 | |
| SCHEMBL11354534 | 0.71 | CYP1A2 (0.48) | CYP1A2PBRM1HSD17B10TSHRALDH1A1 | |
| SCHEMBL11363652 | 0.70 | CYP1A2 (0.48) | CYP1A2HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL15016533 | 0.70 | ALOX15 (0.39) | CYP1A2HSD17B10TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4244966-A | 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |