Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLK | P51451 | 5/20 | 0.57 |
| ▸ | BTK | Q06187 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 4/20 | 0.51 |
| ▸ | MMP9 | P14780 | 4/20 | 0.51 |
| ▸ | MMP8 | P22894 | 4/20 | 0.51 |
| ▸ | MMP13 | P45452 | 4/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136378 | 0.96 | MMP2 (0.53) | BLKBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL1136398 | 0.93 | BTK (0.59) | BLKBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL1136390 | 0.89 | NR2E3 (0.59) | KDM4EMAPTLMNAMMP2MMP9 | |
| SCHEMBL1136423 | 0.87 | CHEK2 (0.52) | BLKBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL1136389 | 0.87 | DGAT1 (0.54) | BLKBTKKDM4EMAPTHPGD | |
| SCHEMBL1136406 | 0.85 | BLK (0.48) | BLKBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL1136433 | 0.84 | BTK (0.57) | BLKBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL1136434 | 0.84 | BTK (0.57) | BLKBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL5306882 | 0.84 | MMP2 (0.66) | MAPTMMP2MMP9MMP8MMP13 | |
| SCHEMBL4487422 | 0.84 | MMP2 (0.58) | KDM4EMAPTALDH1A1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919910-B1 | AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2011-02-23 | — | — | EP | claimed |
| EP-1919910-B1 | AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2011-02-23 | — | — | EP | disclosed |