Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874787 | 0.94 | TSHR (0.51) | TSHRKCNH2KCNJ1CYP19A1IDO1 | |
| SCHEMBL28771941 | 0.86 | KCNH2 (0.58) | KCNH2 | |
| SCHEMBL5391363 | 0.84 | KCNH2 (0.49) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| Alcohol SCHEMBL6170225 | 0.82 | ACHE (0.50) | TSHRKCNH2KCNJ1 | |
| SCHEMBL15807622 | 0.82 | KCNH2 (0.50) | TSHRKCNH2KCNJ1CYP19A1 | |
| SCHEMBL3248064 | 0.80 | TSHR (0.54) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| Alcohol SCHEMBL4228476 | 0.80 | CA1 (0.41) | TSHR | |
| SCHEMBL3258334 | 0.79 | CA2 (0.50) | TSHRKCNH2 | |
| SCHEMBL693396 | 0.78 | TSHR (0.51) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL1827937 | 0.78 | IDO1 (0.58) | TSHRKCNH2KCNJ1CYP19A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4294986-A | Novel para-phenylalkoxy phenylurea and thiourea compounds and herbicidal use thereof | AMERICAN CYANAMID CO. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4289903-A | PREEMERGENCE AND POSTEMERGENCE | AMERICAN CYANAMID COMPANY (US) | 1981-09-15 | — | — | US | disclosed |