Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.56 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.56 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.56 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11364847 | 1.00 | BCHE (0.56) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11363162 | 0.84 | PKM (0.47) | HRH4HRH3RAB9ASMN1; SMN2QPCT | |
| SCHEMBL11363159 | 0.84 | PKM (0.47) | HRH4HRH3RAB9ASMN1; SMN2QPCT | |
| SCHEMBL11364661 | 0.82 | BCHE (0.56) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11449162 | 0.82 | BCHE (0.56) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11364449 | 0.81 | NPC1 (0.53) | BCHEHRH4RAB9ASMN1; SMN2 | |
| SCHEMBL11364451 | 0.81 | NPC1 (0.53) | BCHEHRH4RAB9ASMN1; SMN2 | |
| SCHEMBL11361088 | 0.80 | HRH4 (0.44) | TSHRHRH4HRH3TP53RAB9A | |
| SCHEMBL11361085 | 0.80 | HRH4 (0.44) | TSHRHRH4HRH3TP53RAB9A | |
| SCHEMBL11360400 | 0.79 | PKM (0.49) | HRH4RAB9ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293699-A | CONTAINING A BENZIMIDAZOLE OR 3-/5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4221802-A | Pharmacologically active guanidine compounds for inhibiting H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |