Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.56 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.56 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.56 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11364669 | 0.84 | BCHE (0.55) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11363167 | 0.84 | PKM (0.50) | RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL11364456 | 0.82 | BCHE (0.54) | BCHERAB9ASMN1; SMN2LMNA | |
| SCHEMBL11364822 | 0.82 | BCHE (0.56) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11364847 | 0.82 | BCHE (0.56) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11361092 | 0.80 | PKM (0.43) | TSHRTP53RAB9ASMN1; SMN2PKM | |
| SCHEMBL11346779 | 0.80 | BCHE (0.63) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL11360407 | 0.79 | PKM (0.52) | RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL11354873 | 0.78 | HTT (0.51) | TSHRSMN1; SMN2PKMLMNA | |
| SCHEMBL11363625 | 0.77 | SMN1; SMN2 (0.45) | BCHERAB9ASMN1; SMN2PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4221802-A | Pharmacologically active guanidine compounds for inhibiting H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4070475-A | THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-01-24 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |