Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11366324 | 1.00 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2HRH4HRH3HRH2 | |
| SCHEMBL11368212 | 0.82 | HRH4 (0.38) | HRH4HRH3HRH2 | |
| SCHEMBL11364167 | 0.81 | HRH4 (0.48) | HRH4HRH3HRH2 | |
| SCHEMBL11366341 | 0.80 | ITGB3 (0.32) | — | |
| SCHEMBL11370193 | 0.77 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HRH4HRH2 | |
| SCHEMBL11370196 | 0.77 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HRH4HRH2 | |
| SCHEMBL11368209 | 0.73 | HRH4 (0.53) | SMN1; SMN2HRH4HRH3HRH2 | |
| SCHEMBL11368204 | 0.73 | HRH4 (0.53) | SMN1; SMN2HRH4HRH3HRH2 | |
| SCHEMBL11364154 | 0.71 | ITGB3 (0.33) | HRH4HRH3 | |
| SCHEMBL11542809 | 0.69 | HRH4 (0.57) | ALDH1A1SMN1; SMN2HRH4HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293699-A | CONTAINING A BENZIMIDAZOLE OR 3-/5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4228291-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |