Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 10/20 | 0.46 |
| ▸ | HTR1B | P28222 | 8/20 | 0.46 |
| ▸ | HTR1D | P28221 | 7/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11362476 | 0.85 | CYP2D6 (0.57) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL2537626 | 0.85 | HTR2A (0.74) | HTR2AMEN1KMT2AHTR6HTR1A | |
| SCHEMBL3816723 | 0.85 | HTR2A (0.73) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL11360288 | 0.81 | HTR2A (0.52) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL4604830 | 0.81 | CYP2C19 (0.51) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL4605682 | 0.79 | MTNR1A (0.55) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL27596056 | 0.79 | HTR2A (0.47) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL27596055 | 0.79 | MTNR1A (0.52) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL10919832 | 0.76 | HTR2A (0.71) | HTR2AMEN1KMT2AHTR6MTNR1A | |
| SCHEMBL8291070 | 0.76 | ALDH1A1 (0.47) | HTR2AMEN1KMT2AHTR6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255432-A | ANTIHYPERTENSIVE AGENTS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, ANTIVASOSPASTIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-03-10 | — | — | US | disclosed |