Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 13/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17026814 | 0.85 | AR (0.49) | AR | |
| SCHEMBL15828685 | 0.81 | AR (0.41) | AR | |
| SCHEMBL4415891 | 0.75 | GAA (0.42) | ARNR1H3NR1H2MEN1ALOX15 | |
| SCHEMBL11249086 | 0.74 | MEN1 (0.38) | ARNR1H3NR1H2MEN1ALOX15 | |
| SCHEMBL8641161 | 0.74 | BRD4 (0.44) | AR | |
| SCHEMBL9035064 | 0.74 | AR (0.43) | AR | |
| SCHEMBL9035075 | 0.74 | AR (0.43) | AR | |
| SCHEMBL11472931 | 0.73 | AR (0.42) | ARNR1H3NR1H2MEN1ALOX15 | |
| SCHEMBL3626489 | 0.72 | TRPV1 (0.43) | ARNR1H3NR1H2MEN1ALOX15 | |
| SCHEMBL9845271 | 0.72 | AR (0.41) | ARMEN1ALOX15KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251534-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |