Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3625724 | 0.92 | GAA (0.42) | ARNR1H3NR1H2GAARORC | |
| SCHEMBL4415891 | 0.85 | GAA (0.42) | ARNR1H3NR1H2GAARORC | |
| SCHEMBL6754193 | 0.85 | AR (0.49) | ARGAAMEN1MAPK1KMT2A | |
| SCHEMBL6754239 | 0.85 | AR (0.49) | ARGAAMEN1MAPK1KMT2A | |
| SCHEMBL6754237 | 0.85 | AR (0.49) | ARGAAMEN1MAPK1KMT2A | |
| SCHEMBL13986217 | 0.80 | AR (0.41) | ARALOX15HSD17B10ESR1ESR2 | |
| SCHEMBL16564686 | 0.78 | GAA (0.46) | NR1H3NR1H2GAARORCNR1I2 | |
| SCHEMBL11249086 | 0.75 | MEN1 (0.38) | ARNR1H3NR1H2RORCMEN1 | |
| SCHEMBL11358716 | 0.74 | DRD2 (0.51) | ARNR1H3NR1H2GAARORC | |
| SCHEMBL3626397 | 0.74 | NR1H3 (0.42) | NR1H3NR1H2GAARORCESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4218448-A | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-08-19 | — | — | US | disclosed |