Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PTGFR | P43088 | 3/20 | 0.43 |
| ▸ | SLCO2A1 | Q92959 | 3/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372858 | 1.00 | TBXA2R (0.43) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11374469 | 0.85 | PTGER4 (0.44) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11366996 | 0.85 | TBXA2R (0.43) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11365340 | 0.84 | TBXA2R (0.42) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11307756 | 0.84 | TBXA2R (0.51) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11304538 | 0.84 | TBXA2R (0.51) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11370789 | 0.80 | TBXA2R (0.52) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL16490649 | 0.79 | SLCO2A1 (0.56) | TBXA2RPTGFRSLCO2A1PTGER1PTGER3 | |
| SCHEMBL11568205 | 0.77 | PTGFR (0.31) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 | |
| SCHEMBL11380062 | 0.76 | MEN1 (0.44) | TBXA2RLMNAALDH1A1PTGFRSLCO2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163016-A | ANTISECRETORY AGENTS, HYPOTENSIVE AGENTS, ANTIULCER AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-07-31 | — | — | US | claimed |
| US-4306078-A | 16-Substituted prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4260818-A | ANTISECRETORY, ANTIULCER, HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4212993-A | 11-ALKYL-13-SATURATED-15-KETO-16-FLUORO, -ALKYL OR -TRIFLUOROMETHYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4204074-A | ANTISECRETORY, HYPOTENSIVE, ANTIULCER | HOFFMANN-LA ROCHE INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4163016-A | ANTISECRETORY AGENTS, HYPOTENSIVE AGENTS, ANTIULCER AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-07-31 | — | — | US | disclosed |