Trimazosin

Trimazosin

SCHEMBL113671

COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 1.00
ADRA2C P18825 1/20 1.00
ADRA1A P35348 1/20 1.00
KCNH2 Q12809 1/20 1.00
CFD P00746 17/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trimazosin SCHEMBL122583 0.99 HTR1A (0.98) HTR1AADRA2CADRA1AKCNH2CFD
Trimazosin SCHEMBL10363255 0.98 HTR1A (0.96) HTR1AADRA2CADRA1AKCNH2CFD
Trimazosin SCHEMBL1650275 0.97 HTR1A (0.95) HTR1AADRA2CADRA1AKCNH2CFD
SCHEMBL10952832 0.91 HTR1A (0.83) HTR1AADRA2CADRA1AKCNH2CFD
Hydrochloric Acid SCHEMBL10957694 0.90 HTR1A (0.81) HTR1AADRA2CADRA1AKCNH2CFD
SCHEMBL11814278 0.89 HTR1A (0.80) HTR1AADRA2CADRA1AKCNH2CFD
SCHEMBL10951375 0.89 ADRA1A (0.80) HTR1AADRA2CADRA1AKCNH2CFD
SCHEMBL10986215 0.85 ADRA1A (0.75) HTR1AADRA2CADRA1AKCNH2
SCHEMBL11813620 0.85 HTR1A (0.74) HTR1AADRA2CADRA1AKCNH2CFD
SCHEMBL10957239 0.83 HTR1A (0.70) HTR1AADRA2CADRA1AKCNH2CFD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4095 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727545-A2 COMBINATION TREATMENTS FOR DEPRESSION AND OTHER DISORDERS Neurawell Therapeutics (US) 2026-04-22 EP claimed
US-20250222008-A1 EYEDROPS CONTAINING AN ALPHA1-BLOCKER FOR INHIBITING MYOPIA PROGRESSION TSUBOTA LABORATORY, INC. (JP) 2025-07-10 US claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 US claimed
US-20250186415-A1 EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT 2025-06-12 US claimed
EP-4489858-A1 EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS Harrow IP, LLC (US) 2025-01-15 EP claimed
WO-2024259412-A2 COMBINATION TREATMENTS FOR DEPRESSION AND OTHER DISORDERS Neurawell Therapeutics (US) 2024-12-19 WO claimed
US-20240216375-A1 USE OF SYMPATHETIC ACTIVATION INHIBITOR AND/OR ALPHA 1-ADRENERGIC RECEPTOR INHIBITOR IN PREPARING MEDICINE FOR TREATING DRY EYES EYE INSTITUTE OF SHANDONG FIRST MEDICAL UNIVERSITY (CN) 2024-07-04 US claimed
WO-2023192319-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA (US) 2023-10-05 WO claimed
WO-2023183932-A2 MONOBODIES BINDING TO INTERCELLULAR ADHESION MOLECULE 2 (ICAM-2) NEW YORK UNIVERSITY (US) 2023-09-28 WO claimed
WO-2023172240-A1 EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS HARROW IP, LLC (US) 2023-09-14 WO claimed
EP-0178122-A2 Improved piroxicam-containing antiinflammatory compositions PFIZER INC. (US) 1986-04-16 EP claimed
EP-0178124-A1 Improved antiinflammatory salts of piroxicam PFIZER INC. (US) 1986-04-16 EP claimed
US-4582832-A Trimazosin as an anti-atherosclerosis agent PFIZER INC. (US) 1986-04-15 US claimed
US-4567179-A Antiinflammatory salts of piroxicam PFIZER, INC. (US) 1986-01-28 US claimed
US-4550164-A HYPOTENSIVE AGENTS; REACTING ISOBUTYLENE CARBONATE WITH SUBSTITUTED PIPERAZINE PFIZER INC. (US) 1985-10-29 US claimed
US-4532135-A Treating renal damage by administering vasodilator having postsynaptic alpha-adrenoceptor blocking activity and antihyperlipidemic characteristics EDWARDS K DAVID G 1985-07-30 US claimed
EP-0060081-B1 PIPERAZINOQUINAZOLINE ANTIHYPERTENSIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND IMMUNOGENIC PROTEIN CONJUGATES FORMED FROM THEM PFIZER INC. (US) 1985-07-17 EP claimed
EP-0103387-A2 Long-acting matrix tablet formulations PFIZER INC. (US) 1984-03-21 EP claimed
EP-0060081-A2 Piperazinoquinazoline antihypertensives, processes for preparing them, pharmaceutical compositions containing them, and immunogenic protein conjugates formed from them PFIZER INC. (US) 1982-09-15 EP claimed
US-4130647-A PRAZOSIN OR TRIMAZOSIN OR SALTS PFIZER INC. (US) 1978-12-19 US claimed