Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11366588 | 0.86 | ALDH1A1 (0.51) | MAPTACHESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11568065 | 0.86 | MIF (0.49) | MAPTHSD17B10SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL11208894 | 0.86 | MAPT (0.59) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL11350394 | 0.85 | MAPT (0.50) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL31165708 | 0.82 | SMN1; SMN2 (0.46) | MAPTACHEHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL4040996 | 0.82 | SMN1; SMN2 (0.46) | MAPTACHEHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL6589380 | 0.81 | TDP1 (0.43) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL11363412 | 0.79 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL6589377 | 0.79 | TDP1 (0.43) | MAPTSMN1; SMN2ALDH1A1KMT2AHTT | |
| SCHEMBL11475471 | 0.78 | MAPT (0.43) | MAPTKMT2AMEN1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277477-A | TREATING CARDIAC ARRHYTHMIA | BASF AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |
| EP-0000727-B1 | 3-(4-(1,3-DIAZACYCLOALKENE-2-YL)-PHENYL)-1,2-BENZISOTHIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM. | BASF Aktiengesellschaft (DE) | 1980-08-20 | — | — | EP | disclosed |
| US-4206217-A | ANTIARRHYTHMIA | BASF AKTIENGESELLSCHAFT (DE) | 1980-06-03 | — | — | US | disclosed |
| EP-0000750-A1 | 1,2-Benzisothiazoles and process for their preparation | BASF Aktiengesellschaft (DE) | 1979-02-21 | — | — | EP | disclosed |
| EP-0000727-A1 | 3-(4-(1,3-Diazacycloalkene-2-yl)-phenyl)-1,2-benzisothiazoles, process for their preparation and medicaments containing them. | BASF Aktiengesellschaft (DE) | 1979-02-21 | — | — | EP | disclosed |