Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 7/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367791 | 1.00 | HTR1A (0.35) | HTR1AHTR1DHRH4HRH2QPCT | |
| SCHEMBL11360411 | 0.83 | HRH4 (0.43) | HRH4HRH2QPCTHRH3 | |
| SCHEMBL11360423 | 0.83 | HRH4 (0.43) | HRH4HRH2QPCTHRH3 | |
| SCHEMBL11360416 | 0.81 | HRH4 (0.37) | HRH4HRH2QPCTHRH3CYP3A4 | |
| SCHEMBL11367803 | 0.80 | HRH4 (0.50) | HRH4HRH2QPCTHRH3CYP3A4 | |
| SCHEMBL11353703 | 0.79 | BCHE (0.38) | HRH4HRH2HRH3 | |
| SCHEMBL11375685 | 0.79 | BCHE (0.38) | HRH4HRH2HRH3 | |
| SCHEMBL11447191 | 0.79 | BCHE (0.38) | HRH4HRH2HRH3 | |
| SCHEMBL9333765 | 0.79 | BCHE (0.41) | HRH4HRH2QPCTCYP3A4CYP2D6 | |
| SCHEMBL9333762 | 0.79 | BCHE (0.41) | HRH4HRH2QPCTCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293699-A | CONTAINING A BENZIMIDAZOLE OR 3-/5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4287198-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-09-01 | — | — | US | disclosed |
| US-4228291-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4221802-A | Pharmacologically active guanidine compounds for inhibiting H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4070475-A | THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-01-24 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |