Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.35 |
| ▸ | HRH2 | P25021 | 5/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11353703 | 1.00 | BCHE (0.38) | BCHEACHEHRH4HRH2HRH3 | |
| SCHEMBL11447191 | 0.92 | BCHE (0.38) | BCHEACHEHRH4HRH2HRH3 | |
| SCHEMBL11360423 | 0.87 | HRH4 (0.43) | BCHEACHEHRH4HRH2HRH3 | |
| SCHEMBL11360411 | 0.87 | HRH4 (0.43) | BCHEACHEHRH4HRH2HRH3 | |
| SCHEMBL11360416 | 0.81 | HRH4 (0.37) | BCHEACHEHRH4HRH2HRH3 | |
| SCHEMBL11353708 | 0.81 | BCHE (0.39) | BCHEACHEHRH4HRH2HRH3 | |
| SCHEMBL11367791 | 0.79 | HTR1A (0.35) | HRH4HRH2HRH3 | |
| SCHEMBL11371217 | 0.79 | BCHE (0.39) | BCHEACHEHRH4HRH2 | |
| SCHEMBL11367808 | 0.79 | HTR1A (0.35) | HRH4HRH2HRH3 | |
| SCHEMBL11353712 | 0.79 | BCHE (0.39) | BCHEACHEHRH4HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4287198-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-09-01 | — | — | US | disclosed |
| US-4228291-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |