Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15660720 | 0.81 | RARB (0.54) | TSHREPHX2NR1H4ALDH1A1MAPT | |
| SCHEMBL11367999 | 0.80 | CA12 (0.46) | TSHRALDH1A1MAPT | |
| SCHEMBL31310068 | 0.80 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| Ammonia Solution, Strong SCHEMBL27525448 | 0.79 | RARB (0.53) | TSHREPHX2NR1H4ALDH1A1MAPT | |
| SCHEMBL9851250 | 0.79 | STAT3 (0.37) | EPHX2NR1H4ACLY | |
| SCHEMBL7052993 | 0.78 | TSHR (0.57) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL8506562 | 0.78 | RARB (0.56) | TSHRALDH1A1MAPT | |
| SCHEMBL25221325 | 0.77 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL9185167 | 0.77 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL14037607 | 0.77 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4260771-A | VASODILATORS, ANTICOAGULANTS, IMMUNOLOGY | MERCK & CO., INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4225609-A | Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids | MERCK & CO., INC. (US) | 1980-09-30 | — | — | US | disclosed |