Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367617 | 0.82 | CYP1A2 (0.66) | HTR2AHTR2CHTR2BPBRM1HSD17B10 | |
| SCHEMBL11350233 | 0.82 | HSD17B10 (0.43) | PBRM1HSD17B10CYP1A2KMT2AGAA | |
| SCHEMBL11352016 | 0.79 | KDM4E (0.47) | HSD17B10CYP1A2GAA | |
| SCHEMBL11355710 | 0.77 | HTR2A (0.45) | HTR2AHTR2CHTR2BPBRM1CYP1A2 | |
| SCHEMBL31133079 | 0.74 | HSD17B10 (0.73) | HTR2AHTR2CHTR2BHSD17B10CYP1A2 | |
| SCHEMBL18215418 | 0.74 | HSD17B10 (0.73) | HTR2AHTR2CHTR2BHSD17B10CYP1A2 | |
| SCHEMBL2645035 | 0.74 | HSD17B10 (0.73) | HTR2AHTR2CHTR2BHSD17B10CYP1A2 | |
| SCHEMBL18215470 | 0.74 | HSD17B10 (0.73) | HTR2AHTR2CHTR2BHSD17B10CYP1A2 | |
| SCHEMBL11363508 | 0.73 | HSD17B10 (0.47) | HSD17B10CYP1A2GAA | |
| SCHEMBL11354534 | 0.70 | CYP1A2 (0.48) | HTR2AHTR2CHTR2BPBRM1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4244966-A | 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |