Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CTH | P32929 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11363652 | 0.87 | CYP1A2 (0.48) | KDM4ESMN1; SMN2HPGDCYP1A2POLL | |
| SCHEMBL11350233 | 0.79 | HSD17B10 (0.43) | KDM4ESMN1; SMN2HPGDCYP1A2HSD17B10 | |
| SCHEMBL11368351 | 0.79 | HTR2A (0.47) | CYP1A2HSD17B10GAA | |
| SCHEMBL11362493 | 0.79 | POLL (0.42) | KDM4EHPGDCYP1A2POLLALDH1A1 | |
| SCHEMBL19249656 | 0.77 | POLL (0.51) | KDM4EHPGDPOLLALDH1A1TP53 | |
| SCHEMBL11367277 | 0.73 | ATM (0.56) | KDM4ECYP1A2ALDH1A1HSD17B10CA1 | |
| SCHEMBL31133079 | 0.72 | HSD17B10 (0.73) | CYP1A2HSD17B10GAA | |
| SCHEMBL18215418 | 0.72 | HSD17B10 (0.73) | CYP1A2HSD17B10GAA | |
| SCHEMBL18215470 | 0.72 | HSD17B10 (0.73) | CYP1A2HSD17B10GAA | |
| SCHEMBL2645035 | 0.72 | HSD17B10 (0.73) | CYP1A2HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4244966-A | 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |