Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | ITK | Q08881 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | TTK | P33981 | 2/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.51 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | WEE1 | P30291 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12864181 | 1.00 | FLT3 (0.54) | FLT3SRCITKAURKAAURKB | |
| SCHEMBL12864586 | 0.92 | FLT3 (0.64) | FLT3SRCITKAURKAAURKB | |
| SCHEMBL12864804 | 0.82 | ITK (0.54) | FLT3SRCITKKITJAK2 | |
| SCHEMBL10063009 | 0.79 | ITK (0.85) | FLT3SRCITKAURKAAURKB | |
| SCHEMBL12864591 | 0.78 | ITK (0.53) | FLT3SRCITKKITACVR1 | |
| SCHEMBL13209779 | 0.74 | TGFBR1 (0.42) | FLT3SRCITKKITABL1 | |
| SCHEMBL10062949 | 0.70 | ITK (1.00) | FLT3SRCITKAURKAAURKB | |
| SCHEMBL15850183 | 0.70 | AURKA (0.74) | FLT3SRCITKAURKAAURKB | |
| SCHEMBL1136737 | 0.70 | SRC (0.40) | FLT3SRCITKAURKAAURKB | |
| SCHEMBL11000997 | 0.69 | TTK (1.00) | FLT3SRCITKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919905-B1 | 3,5-DISUBSTITUTED PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY OF NON-RECPTOR TYROSINE KINASES | VERTEX PHARMA (US) | 2011-02-23 | — | — | EP | disclosed |