Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 6/20 | 0.53 |
| ▸ | KIT | P10721 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13209779 | 0.87 | TGFBR1 (0.42) | ITKKITSRCFLT3TGFBR1 | |
| SCHEMBL12864804 | 0.83 | ITK (0.54) | ITKKITSRCFLT3TGFBR1 | |
| SCHEMBL1136845 | 0.78 | FLT3 (0.54) | ITKKITSRCFLT3ACVR1 | |
| SCHEMBL12864181 | 0.78 | FLT3 (0.54) | ITKKITSRCFLT3ACVR1 | |
| SCHEMBL12864182 | 0.70 | ITK (0.43) | ITKKITSRCFLT3 | |
| SCHEMBL10063086 | 0.69 | ITK (1.00) | ITKKITSRCFLT3 | |
| SCHEMBL12864586 | 0.69 | FLT3 (0.64) | ITKKITSRCFLT3 | |
| SCHEMBL3372750 | 0.66 | ADRB1 (0.61) | MAOB | |
| SCHEMBL31684829 | 0.65 | ADRB2 (0.50) | TGFBR1ACVR1MAOB | |
| SCHEMBL12431850 | 0.64 | ADRB2 (0.70) | PIM1PIM3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919905-B1 | 3,5-DISUBSTITUTED PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY OF NON-RECPTOR TYROSINE KINASES | VERTEX PHARMA (US) | 2011-02-23 | — | — | EP | disclosed |
| US-7786120-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786120-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-31 | — | — | US | disclosed |
| US-20070185125-A1 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-09 | — | — | US | disclosed |
| US-20070185125-A1 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-09 | — | — | US | disclosed |
| WO-2007027528-A2 | 3,5-DISUBSTITUTED PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY OF NON-.RECEPTOR TYROSINE KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185125-A1 | Pyridones useful as inhibitors of kinases | MAP3K20, MAP3K6, MAP3K5 | ITK 401/4885KIT 907/4885SRC 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.